Agenda

May 4, 2023 – May 6, 2023

Wednesday, May 3, 2023

6:30 PM – Faculty dinner & group photo

Current Landscapes of Melanoma

Skyline Terrace & Skyline A Room

JW Marriott

Thursday, May 4, 2023

7:30 AM – Welcome and Ancillary Breakfast Mini-symposium sponsored by Castle Biosciences
Location: Skyline B/C on the 21st Floor

An Update on the 31-GEP in Cutaneous Melanoma; 5-year Outcomes from the NCI SEER Cancer Registry (NON CME Breakfast Lecture)

Speaker: David Hyams, MD

The Management of Melanoma: Can we use GEP to Help Guide Treatment and Surveillance

Speaker: Jonathan Zager, MD

Location: Metropolitan Ballroom
8:15 AM – 9:10 AM - CANCER MICROENVIRONMENT

Moderated by: Stanley Leong, MD

8:15 AM – 8:35 AM - Origins and behavior of disseminated tumor cells during minimal residual disease

Speaker: M. Soledad Sosa, PhD

8:35 AM – 8:55 AM - Cancer dormancy and its clinical implications

Speaker: Shelly R. Peyton, PhD

8:55 AM – 9:10 AM - Panel Q&A

9:10 AM – 9:30 AM - Coffee Break

9:30 AM – 11:05 AM - SPATIAL SYSTEMS IMMUNOLOGY IN CANCER

Moderated by: Ian Watson, PhD

9:30 AM – 9:50 AM - Spatially mapping the immune landscapes of melanoma metastases

Speaker: Ian Watson, PhD

9:50 AM – 10:10 AM - Role of lymph node metastasis in systemic immune surveillance

Speaker: Nathan Reticker-Flynn, PhD

10:10 AM – 10:30 AM - Lymphatic trafficking of immune cells and insights for cancer

Speaker: David G. Jackson, PhD

10:30 AM – 10:50 AM - Single-cell epigenomic and transcriptomic dissection of melanoma immunotherapy response

Speaker: Jiekun Yang, PhD

10:50 AM – 11:05 AM - Panel Q & A

11:05 AM – 12:20 PM - RESISTANCE TO CANCER THERAPY

Moderated by: Jonathan Sleeman, PhD

11:05 AM – 11:25 AM - Development of resistance in cancer to therapy resulting in recurrence and metastasis

Speaker: Jonathan Sleeman, PhD

11:25 AM – 11:45 AM - The host immunological response to cancer therapy and its clinical implications

Speaker: Yuval Shaked, PhD

11:45 AM – 12:05 PM - Molecular inhibition overcoming treatment resistance in melanoma

Speaker: Mohammed Kashani-Sabet, MD

12:05 PM – 12:20 PM - Panel Q&A

12:20 PM – 1:20 PM - Box Lunch

1:20 PM – 2:55 PM - BIOLOGY AND CLINICAL IMPLICATIONS OF SENTINEL LYMPH NODES

Moderated by: David Nathanson, MD

1:20 PM – 1:40 PM - Donald L. Morton Memorial Lecture: The concealed revealed

Speaker: David Nathanson, MD

1:40 PM – 2:00 PM - Sentinel lymph nodes in melanoma: necessary as ever for optimal treatment

Speaker: Mark Faries, MD

2:00 PM – 2:20 PM - Sentinel lymph nodes and molecular markers in breast cancer

Speaker: Theresa L. Schwartz, MD, MS

2:20 PM – 2:40 PM - Prediction of outcome in melanoma: a review and comparison of available tests

Speaker: Jane Messina, MD

2:40 PM – 2:55 PM - Panel Q&A

2:55 PM – 3:15 PM - Coffee/Exhibitor Break

3:15 PM – 4:50 PM - THE HENRY FORD HEALTH SYMPOSIUM: MOLECULAR MECHANISMS OF BREAST CANCER METASTASIS

Moderated by: David Nathanson, MD

3:15 PM – 3:35 PM - Multifaceted roles of lymphatic endothelial cells in cancer metastasis

Speaker: Lothar C. Dieterich, PhD

3:35 PM – 3:55 PM - The evolving cancer-niche interaction during bone metastasis

Speaker: Xiang Zhang, PhD

3:55 PM – 4:15 PM - Anatomic and molecular characteristics associated with Breast Cancer Metastasis

Speaker: Dhananjay A. Chitale, MD, MBA

4:15 PM – 4:35 PM - Can we cure metastatic breast cancer?

Speaker: Lajos Pusztai, MD, DPhil

4:35 PM – 4:50 PM - Panel Discussion

5:00 PM – 7:00 PM - Poster Session/Reception

Moderated by: Stanley Leong, MD and Jane Messina, MD

Posters:

Impact of Adjuvant Immunotherapy on Overall Survival in a Contemporary Cohort of Patients with Stage III Melanoma (Sharon)

Combining the 31-gene expression profile test for cutaneous melanoma with the American Joint Committee on Cancer staging identifies the highest-risk patients with stage I-II disease (Morgan-Linnell)

Marking Melanoma Metastases Using Radar-Guided Localization in Patients Receiving Neoadjuvant Therapy (Beekman)

Distant lymphoid organs extend ICB efficacy after TDLN dissection (Zhou)

Selective Hepatic Vein Sampling for Enriched Circulating Tumor Cell Collection in Patients with Liver Dominant Malignancy (Hui)

Population-based prognostic instrument (SweMR 2.0) for melanoma-specific survival - a tool for individualised treatment decisions (Olofsson Bagge)

Multimodal Analysis of Primary Breast Tumors, Lymph Nodes, Bone Metastasis, and Patient-Derived Xenografts in TNBC Facilitate the Study of Breast Cancer Metastasis (Jiagge)

Paracrine pathways mediate metastasis of breast cancer to lymphatics (Ji)

A Single-Institution Review of Contemporary Treatment of Surgically Unresectable Melanoma In-Transit Metastases (DePalo)

Exosomal miRNA levels associated with immunotherapy response in metastatic clear cell renal cell carcinoma patients (Asadullina)

Clinical significance of elevated postoperative serum troponin levels following percutaneous hepatic perfusion: a single institution experience (Perez)

High-Risk Melanoma Stage IIB and IIC Patterns of Recurrence (Coogan)

Тumor-associated macrophages and its correlation with progression of prostate cancer (Enikeeva)

FOXC2 dysregulation is associated with delayed wound healing and exuberant granulation tissue (Granoski)

Dinner on own

Friday, May 5, 2023

7:30 AM – Ancillary Breakfast Mini-symposium sponsored by Cardinal Health
Location: Skyline B/C on the 21st Floor

Identification of Sentinel Lymph Nodes by LYMPHOSEEK® (technetium Tc 99m tilmanocept) injection (NON CME Breakfast Lecture)

Speaker: Stanley Leong, MD

Location: Metropolitan Ballroom
8:15AM – 9:10 AM - CANCER METASTASIS THROUGH THE LYMPHOVASCULAR SYSTEM

Moderated by: James Warneke, MD

8:15 AM – 8:35 AM - Lymphatic systemomics and cancer

Speaker: Marlys Witte, MD

8:35 AM – 8:55 AM - Cancer metastasis through the lymphatic versus blood vessels

Speaker: Stanley P. Leong, MD

8:55 AM – 9:10 AM - Panel Q&A

9:10 AM – 10:25 AM - NOVEL FRONTIERS IN THE TREATMENT OF METASTATIC MELANOMA

Moderated by: Ajay Maker, MD

9:10 AM – 9:30 AM - Neoadjuvant therapy for advanced metastatic melanoma nodal disease

Speaker: Giorgos Karakousis, MD

9:30 AM – 9:50 AM - Updates on intralesional monotherapy and combination therapy for in transit metastases from metastatic melanoma

Speaker: Jonathan S. Zager, MD

9:50 AM – 10:10 AM - Updates on regional perfusions for in-transit lymphatic metastasis of the limb and uveal melanoma metastatic to the liver

Speaker: Roger Olofsson Bagge, MD, PhD

10:10 AM – 10:25 AM - Panel Discussion

10:25 AM – 10:55 AM - Coffee/Exhibitor Break

10:55 AM – 11:50 AM - ONCOLYMPHOLOGY: IMMUNE SYSTEM AND CANCER

Moderated by: Stanley Leong, MD

10:55 AM – 11:15 AM - T cell repertoire against cancer antigens

Speaker: Mark M. Davis, PhD

11:15 AM – 11:35 AM - Perioperative considerations for tumor tissue procurement to obtain tumor-infiltrating lymphocytes for adoptive cell therapy

Speaker: John E. Mullinax, MD

11:35 AM – 11:50 AM - Panel Q&A

11:50 AM – 12:45 PM - PERSONALIZED CANCER THERAPY AND RADIOTHERAPY

Moderated by: Deepti Behl, MD

11:50 AM – 12:10 PM - Immunotherapy and targeted therapy for personalized cancer treatment

Speaker: Kevin Kim, MD

Moderated by: Marlys Witter, MD

12:10 PM – 12:30 PM - Molecular mechanisms of sensitivity and resistance to radiotherapy

Speaker: Baldassarre D. Stea, MD, PhD

12:30 PM – 12:45 PM - Panel Q&A

12:45 PM – 1:45 PM Box Lunch

1:00 PM – 5:30 PM LYMPHEDEMA PROGRAM

The Lymphedema Program is a non-CME event included with conference registration for the Cancer Mets Congress at no additional charge. Patients and healthcare providers can register for the Lymphedema Day independent of the Cancer Metastasis Congress. Snacks and Coffee will be available in the afternoon during this program.

3:00 PM – 5:00 PM Oral Abstract Presentations

Moderated by: Giorgos Karakousis, MD and Roger Olofsson Bagge, MD

Oral Presentations:

RAC1 P29S drives migration and invasion in melanocytes, which is coordinated by the scaffold protein IQGAP1 (Heney)

Exhaustive T-Cell Environment promotes the Invasiveness and Proliferation of Uveal Melanoma (Singh)

Breast cancer cell MHC class II-mediated tumor progression and immune regulation in the draining lymph nodes (Lei)

Tumor suppressor role for microRNA-876 in human melanoma (Khan)

Surgical Management of Clinical Nodal Disease in Merkel Cell Carcinoma (Sharon)

The likelihood of axillary lymph node metastasis in older women with invasive breast cancer (Wood)

Using an ultra-low dose of superparamagnetic iron oxide for sentinel lymph node detection in breast cancer patients - the MAGSNOW feasibility study (Mirzaei)

Retrospective study of the clinical efficacy of MEK inhibitor in advanced NF1-mutant melanoma (Wang)

Dinner on own

Saturday, May 6, 2023

7:30 AM – Ancillary Breakfast (Breakfast Mini-Symposium)

8:00 AM – 9:15 AM - CIRCULATING TUMOR CELLS AND LIQUID BIOPSY

Moderated by: Stanley Leong, MD

8:00 AM – 8:20 AM - Clinical applications of circulating tumor cells in patients with solid tumors

Speaker: Klaus Pantel, MD

8:20 AM – 8:40 AM - Biology and clinical relevance of circulating tumor cells for precision medicine

Speaker: Catherine Alix-Panabieres, PhD

8:40 AM – 9:00 AM - The RPL/RPS gene signature of melanoma CTCs associates with brain metastasis

Speaker: Dario Marchetti, PhD

9:00 AM – 9:15 AM - Panel Q&A

9:15 AM – 9:30 AM - Coffee/Exhibitor Break

9:30 AM – 10:15 AM - Trainee Award Presentations

10:15 AM – 10:45 AM - Meeting Summary and Conclusion

Stanley P. Leong, MD

S. David Nathanson, MD

Jonathan S. Zager, MD

10:45 AM - Adjournment